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To cite this article: Kündig TM. Immunotherapy concepts under investigation. Allergy 2011; 66 (Suppl. 95): 60–62.
AbstractAllergen‐specific immunotherapy (SIT) is effective, but used by only 5% of allergy patients, partly because it requires several years. Intralymphatic immunotherapy (ILIT) administers allergen directly into a subcutaneous lymph node and requires only three injections and a lower...
To cite this article: Bachert C. Treatment of respiratory allergy with allergy immunotherapy tablets. Allergy 2011; 66 (Suppl. 95): 57–59.
AbstractAllergy immunotherapy tablets (AIT) have expanded the treatment options for patients suffering from respiratory allergies. Efficacy is established in adults and children for two different commercially available grass AITs. The ALK grass AIT has an efficacy...
To cite this article: Sørensen P. The future of specific immunotherapy: strategies and challenges for the next generation of allergy vaccines. Allergy 2011; 66 (Suppl. 95): 63–65.
AbstractThe use of specific immunotherapy (SIT) for allergic disorders has recently been extended by introduction of a convenient, tablet‐based, disease‐modifying vaccine against grass pollen allergy. Allergy immunotherapy...
To cite this article: Prescott SL. The influence of early environmental exposures on immune development and subsequent risk of allergic disease. Allergy 2011; 66 (Suppl. 95): 4–6.
AbstractEnvironmental exposures in pregnancy and the early postnatal period affect early immune development. Early immune function and future allergy susceptibility appear to result from a combination of maternal phenotype,...
To cite this article: Linneberg A. The increase in allergy and extended challenges. Allergy 2011; 66 (Suppl. 95):1–3.
AbstractThe prevalence of allergic diseases shows a well‐documented increase in developed countries over several decades. Currently, 20–25% of European adults are affected. Westernisation, urbanisation, and affluence contribute to allergy development, so allergy is expected to increase...
To cite this article: Wahn U. The significance of environmental exposure on the progression of allergic diseases. Allergy 2011; 66 (Suppl. 95):7–9.
AbstractIn addition to strong genetic influences on atopic sensitization and disease development in infancy and childhood, a number of environmental factors modulate clinical and immunological phenotypes early in life and even prenatally. These factors...
To cite this article: Novak N, Allam J‐P. Mucosal dendritic cells in allergy and immunotherapy. Allergy 2011; 66 (Suppl. 95): 22–24.
AbstractThe oral epithelium contains oral mucosal Langerhans cells (oLCs) that constitutively express the high‐affinity IgE‐receptor FcεRI, the lipopolysaccharide receptor CD14 and toll‐like receptor (TLR)4. The distribution of oLCs profoundly differs at distinct oral...
To cite this article: Aalberse R. The role of IgG antibodies in allergy and immunotherapy. Allergy 2011; 66 (Suppl. 95): 28–30.
AbstractIn specific immunotherapy (SIT), a beneficial response is associated with an increase in allergen‐specific IgG4. This does not indicate that IgE‐producing B cells have switched to IgG4 production, because in human DNA, IgE is downstream from IgG4. Thus, by conventional...
To cite this article: de Blay F. Provocation tests as measure of efficacy and dosage. Allergy 2011; 66 (Suppl. 95): 47–49.
AbstractProvocation and challenge tests have been used to understand the pathobiology of asthma, to facilitate diagnosis and to assess therapeutic efficacy and dosage. Current challenge tests expose the patient to ‘natural conditions’, for example, in an allergen chamber. For...
To cite this article: Valovirta E. Effect of AIT in children including potential to prevent the development of asthma. Allergy 2011; 66 (Suppl. 95): 53–54.
AbstractAllergy specific immunotherapy may alter the natural course of allergic disease. Thus, it is of significant importance, particularly in paediatric populations. Four studies using the grass allergy immunotherapy tablet (AIT) for allergic...
To cite this article: Holt PG. Infection and the development of allergic disease. Allergy 2011; 66 (Suppl. 95): 13–15.
AbstractPersistent allergic diseases exemplified by atopic asthma frequently begin during very early life. Epidemiological findings indicate that progression from allergic sensitization to atopic asthma occurs most frequently when atopy is accompanied by early respiratory viral infections...
To cite this article: Meno KH. Allergen structures and epitopes. Allergy 2011; 66 (Suppl. 95): 19–21.
AbstractHuman type 1 hypersensitivity diseases such as allergic rhinoconjunctivitis are characterized by allergen‐specific IgE antibodies produced in allergic individuals after allergen exposure. IgE antibodies bound to receptors on the surface of effector cells trigger an allergic response by interacting...
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